Myocyte Shearing, Myocardial Sheets, and Microtubules
نویسندگان
چکیده
منابع مشابه
Myocyte shearing, myocardial sheets, and microtubules.
The cytoskeleton of cardiac myocytes is a complex network of many interacting protein filaments and associated proteins with multiple functions: it forms structures responsible for maintaining cell shape and contractile filament registration, structural integrity, internal transport and cell division, and scaffolding for several putative signaling cascades.1 The tight coupling between the extra...
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Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...
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The past 20 years have seen tremendous progress in the medical treatment of cardiac diseases, a progress that actually translated into decreased cardiovascular morbidity and mortality in clinical practice.1 Yet evidence accumulates that interventions intended to slow down the progression of chronic heart diseases have approached their limit. This may be one of the reasons why the recent progres...
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We appreciated the review of the current literature to paediatric myocarditis by Lindsay J. May et al (June 2011 issue). Regarding the evolving approach, we would like to underline the meaning of myocardial biopsies even in terms of the shift from coxsackievirus B to adenovirus and, in the past 5 years, to parvovirus B19. In this context, we missed the pathogenetic features of inflammatory card...
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Diastolic dysfunction in volume-overload hypertrophy by aortocaval fistula is characterized by increased passive stiffness of the left ventricle (LV). We hypothesized that changes in passive properties are associated with abnormal myolaminar sheet mechanics during diastolic filling. We determined three-dimensional finite deformation of myofiber and myolaminar sheets in the LV free wall of six d...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000200395.82480.8d